I-ATP disodium usawoti CAS 987-65-5

I-CAS:987-65-5

Ubumsulwa:99%

I-Molecular Formula:I-C10H17N5NaO13P3

Isisindo se-Molecular:531.18

I-EINECS:213-579-1

Isikhathi Sokugcina:iminyaka engu-2

Omqondofana:I-ADENOSINETRIPHOSPHATEDISODIUM; I-ADENOSINETRIPHOSPHATE,DISODIUMSALT; I-ADENYLPYROPHOSPHORICACIDDISODIUMSALT; I-ADENOSINE-5′-TRIPHOSPHATEHYDRATEDISODIUMSALT; I-ADENOSINE-5′-TRIPHOSPHATENA2-SALT; I-ADENOSINE-5′-TRIPHOSPHORICACID,DISODIUM; I-ADENOSINE-5′-TRIPHOSPHORICACIDDISODIUMDIHYDROGENSALT; I-ADENOSINE5′-TRIPHOSPHORICACIDDISODIUMSALT

Shiya Umlayezo Wakho

Imininingwane Yomkhiqizo

Landa

Omaka bomkhiqizo

Iyini i-ATP disodium usawoti CAS 987-65-5?

Usawoti we-ATP disodium iyi-metabolite ye-adenosine, i-nucleoside triphosphate esebenza ngezinto eziningi esetshenziswa njenge-coenzyme yokudlulisa amandla e-intracellular kumaseli. Ihambisa amandla amakhemikhali ngaphakathi kwamaseli ukuze i-metabolism. Usawoti we-ATP disodium usetshenziselwa ukuhlanganiswa kwe-ribose-modified deoxyadenosine diphosphate analogs njenge-P2Y1 receptor ligands.

Ukucaciswa

Ukubukeka	Impushana emhlophe noma i-off-white powder noma i-crystal powder, i-hygroscopic.
Usayizi wezinhlayiya	＞Ama-95% adlula ku-80 mesh.
pH	2.5-3.5
Ukuncibilika	Incibilika emanzini; ayincibiliki ku-ethanol ne-ether.
Oder	Oderless
Okuqukethwe kwamanzi	6.0%~12.0%
I-Chloride	≤0.05%
Usawoti wensimbi	≤0.001%
Izinsimbi ezinzima	≤0.001%
Ukuhola	≤2.0ppm
I-Arsenic	≤1.0ppm

Isicelo

1. Ukusetshenziswa kocwaningo lwezimboni nesayensi
(1) Izinto zokusetshenziswa zezimonyo: zengezwe emikhiqizweni yokunakekelwa kwesikhumba elwa nokuguga, zingathuthukisa ukunwebeka kwesikhumba kanye nokucwebezela ngokwenza kusebenze i-cell metabolism.
(2) Izithasiselo zokudla: ezisetshenziswa njengesithuthukisi somsoco eziphuzweni zezemidlalo kanye nokudla okusebenzayo ukugcwalisa amandla ngokushesha.
2. Izindawo zokwelashwa komtholampilo
(1) Izifo zesistimu yenhliziyo: isetshenziselwa ukwehluleka kwenhliziyo, i-myocarditis, i-myocardial infarction kanye ne-cerebral arteriosclerosis, njll., ngokwenza ngcono i-metabolism yamandla e-myocardial kanye nokwelula imithambo ye-coronary (ukwandisa ukugeleza kwegazi cishe ngama-30%), ukukhulula izimpawu ze-myocardial ischemia. Isibonelo, ezigulini ezine-acute myocardial infarction, i-ATP disodium ingafinyeza isikhathi sokuwa sengxenye ye-ST futhi yehlise inani eliphakeme le-spectrum ye-myocardial enzyme.
(2) Izifo zesistimu yezinzwa: ukwelashwa okusizayo kwe-sequelae ye-cerebral hemorrhage, ukulimala kobuchopho kanye ne-atrophy ye-muscular okuqhubekayo, ngokungena emgodleni wegazi-ubuchopho (i-permeability cishe ngama-65%), ukukhuthaza ukulungiswa kwe-membrane ye-nerve kanye nokuvuselelwa kwenqubo yezinzwa, nokuthuthukisa isivinini sokuhamba kwemizwa.
(3) Izifo ze-Metabolic: Ekwelapheni i-hepatitis kanye ne-cirrhosis, i-ATP disodium ingathuthukisa umsebenzi we-mitochondrial we-hepatocytes, ukusheshisa ukulungiswa kwe-hepatocyte, nokunciphisa amazinga e-ALT ne-AST; iphinde ibe nomphumela osizayo wokuthuthuka ezinkingeni zesifo sikashukela (njenge-peripheral neuropathy).
3. Izindawo zokufaka izicelo ezivelayo
(1) Uhlelo lokulethwa kwezidakamizwa okuhlosiwe: I-ATP disodium ingasetshenziswa njenge-modifier yenkampani yenethiwekhi, ehlanganiswe nama-liposomes noma ama-nanoparticles, ukuze kuzuzwe ukulethwa kwezidakamizwa okuhlosiwe nge-endocytosis ye-receptor-mediated. Isibonelo, ekwelashweni kwesimila, i-ATP-modified nanomedicines ingathuthukisa ukubulawa okukhethekile kwezidakamizwa ze-chemotherapy kumaseli omdlavuza.
(2) Isiko lamaseli kanye nama-biopharmaceuticals: Njengengxenye eyinhloko ye-cell culture medium, i-ATP disodium ingakhuthaza ukukhula nokubonakaliswa kwamaprotheni amaseli e-CHO, amaseli we-HEK293, njll., futhi isetshenziswa kabanzi ekukhiqizeni i-antibody monoclonal.