I-Celastrol CAS 34157-83-0

I-CAS:34157-83-0

I-Molecular Formula:I-C29H38O4

Isisindo se-Molecular:450.61

I-EINECS:636-472-5

Omqondofana:I-CELASTROL(SH); I-CELASTROL; I-Celastrol (Tripterin); I-CELASTROL(P)(SICELA UFONE); (20R)-3-Hydroxy-2-oxo-24-nor-D:A-friedoolean-1(10),3,5,7-tetren-29-oic acid; I-2-Oxo-3-hydroxy-24-norfriedela-1 (10), i-3,5,7-tetraene-29-oic acid; 2-Oxo-3-hydroxy-24-norfriedelane-1(10),3,5,7-tetraene-29-oic acidI-Celasterol

Shiya Umlayezo Wakho

Imininingwane Yomkhiqizo

Landa

Omaka bomkhiqizo

Iyini i-Celastrol CAS 34157-83-0?

I-Celastrol ayincibiliki emanzini, i-soluble ku-dimethyl sulfoxide ne-ethanol anhydrous. Isuselwa kuzithako ezisebenzayo ezilwa nomdlavuza ezitshalweni ezifana ne-Thunder God Vine kanye ne-South Snake Vine emndenini we-Celastraceae. I-proteasome inhibitor esebenzayo, eqinisekisiwe ukuthi idala i-apoptosis yeseli yomdlavuza ngokuvimbela umsebenzi we-proteasome

Ukucaciswa

Into	Ukucaciswa
Iphuzu elibilayo	645.7±55.0 °C(Kubikezelwe)
Ukuminyana	1.2
Iphoyinti lokuncibilika	219-230°C
pKa	4.78±0.70(Kubikezelwe)
λ ubuningi	424nm(MeOH)(lit.)
Izimo zokugcina	-20°C

Isicelo

I-Celastrol isetshenziselwa ukuzimisela kokuqukethwe/ukuhlonza/ukuhlolwa kwezemithi, njll. Imiphumela ye-Pharmacological: Inezakhiwo eziqinile ze-antioxidant, imiphumela ye-anti-cancer angiogenesis, kanye nemiphumela yokulwa ne-rheumatoid. I-proteasome inhibitor esebenzayo, eqinisekisiwe ukuthi idala i-apoptosis yeseli yomdlavuza ngokuvimbela umsebenzi we-proteasome