I-Metronidazole CAS 443-48-1

I-CAS:443-48-1

I-Molecular Formula:I-C6H9N3O3

Isisindo se-Molecular:171.15

I-EINECS:207-136-1

Omqondofana:I-TIMTEC-BB SBB001486; I-1-(2-Hydroxy-1-ethyl) -2-methyl-5-nitroimidazole; I-1-(2-hydroxyethyl) -2-methyl-5-nitroimidazole; I-1-(beta-Hydroxyethyl) -2-methyl-5-nitroimidazole; 1-(beta-Oxyethyl)-2-methyl-5-nitroimidazole; I-1H-Imidazole-1-ethanol, i-2-methyl-5-nitro-; I-1H-Imidazole-1-ethanol, i-2-methyl-5-nitro-; I-1-Hydroxyethyl-2-methyl-5-nitroimidazole; I-2-(2-Methyl-5-nitro-1H-imidazol-1-yl) ithanol; I-2-Methyl-1-(2-hydroxyethyl) -5-nitroimidazole

Shiya Umlayezo Wakho

Imininingwane Yomkhiqizo

Landa

Omaka bomkhiqizo

Iyini iMetronidazole CAS 443-48-1?

I-Metronidazole iyi-crystalline emhlophe noma ephuzi kancane noma i-crystalline powder; Kukhona iphunga elincane, elinokunambitheka okubabayo nokunosawoti omncane. Incibilika kancane ku-ethanol, inyibilika kancane emanzini noma ku-chloroform, futhi inyibilika kancane ku-ether. I-Metronidazole iyinhlanganisela ye-nitrogen equkethe i-heterocyclic ene-alkalinity kanye nokuncibilika kwamanzi okuphansi. Ngokomgomo we-prodrug, i-metronidazole yenziwe i-potassium phosphate ester, eyandisa ukunyibilika kwayo emanzini futhi ingasetshenziswa njengekhambi lomjovo.

Ukucaciswa

Into	Ukucaciswa
Iphuzu elibilayo	301.12°C (isilinganiso esinzima)
Ukuminyana	1.3994 (isilinganiso esinzima)
Iphoyinti lokuncibilika	159-161 °C (okhanyisiwe)
pKa	pKa 2.62(H2O,t =25±0.2,
Izimo zokugcina	2-8°C

Isicelo

I-Metronidazole inomphumela oqinile we-antibacterial kumagciwane amaningi anaerobic futhi isetshenziselwa ukwelapha i-amoebiasis, i-trichomoniasis, kanye nezifo ezibangelwa amagciwane. Ibuye isetshenziselwe ukwelapha i-trichomoniasis yesitho sangasese sowesifazane futhi ibisetshenziselwa i-amoebiasis yamathumbu kanye ne-extraintestinal kusukela ngo-1970. Ukusebenza kwayo kuphezulu, ubuthi buphansi, futhi isetshenziswa kakhulu. Inemiphumela ye-mutagenic kanye ne-teratogenic ekuhlolweni kwezilwane.