Ungase wazi okuncane nge-kojic acid, kodwa i-kojic acid inamanye amalungu omndeni, njenge-kojic dipalmitate. I-Kojic acid dipalmitate iyi-ejenti yokugcoba i-kojic acid ethandwa kakhulu emakethe njengamanje. Ngaphambi kokuba sazi i-kojic acid dipalmitate, ake siqale sifunde ngeyandulelayo – “i-kojic acid”.
I-Kojic Acidikhiqizwa ngokubilisa nokuhlanzwa kwe-glucose noma i-sucrose ngaphansi kwesenzo se-kojise. Indlela yayo yokwenza mhlophe ukuvimbela umsebenzi we-tyrosinase, ukuvimbela umsebenzi we-N-hydroxyindole acid (DHICA) oxidase, nokuvimbela i-polymerization ye-dihydroxyindole (DHI). Kuyisithako esingavamile sokwenza mhlophe esingavimbela ama-enzyme amaningi ngesikhathi esisodwa.
Kodwa i-kojic acid inokukhanya, ukushisa kanye nokungazinzi kwe-ion yensimbi, futhi akulula ukuyimunca yisikhumba, ngakho-ke kwavela ama-derivatives e-kojic acid. Abacwaningi bathuthukise ama-derivatives amaningi e-kojic acid ukuthuthukisa ukusebenza kwe-kojic acid. Ama-derivatives e-Kojic acid awagcini nje ngokuba nendlela efanayo yokwenza mhlophe njenge-kojic acid, kodwa futhi asebenza kangcono kune-kojic acid.
Ngemva kokwenziwa kwe-ester nge-kojic acid, i-monoester ye-kojic acid ingakhiwa, kanti ne-diester nayo ingakhiwa. Njengamanje, i-ejenti yokwenza mhlophe ye-kojic acid ethandwa kakhulu emakethe yi-kojic acid dipalmitate (KAD), okuyi-diesterified derivative ye-kojic acid. Ucwaningo lubonisa ukuthi umphumela wokwenza mhlophe we-KAD ohlanganiswe ne-glucosamine derivatives uzokhula kakhulu.
Ukusebenza kahle kokunakekelwa kwesikhumba kwe-kojic dipalmitate
1) Ukumhlophe: I-Kojic acid dipalmitate isebenza kangcono kune-kojic acid ekuvimbeleni umsebenzi we-tyrosinase esikhumbeni, ngaleyo ndlela ivimbele ukwakheka kwe-melanin, okunomphumela omuhle ekwenzeni isikhumba sibe mhlophe kanye ne-sunscreen.
2) Ukususwa kwamabala: I-Kojic acid dipalmitate ingathuthukisa umbala wesikhumba, futhi ingalwa namabala okuguga, amabala okwelula, amabala kanye nombala ojwayelekile.
Umhlahlandlela wokuhlanganisa izimonyo we-Dipalmitate
I-Kojic acid dipalmitateKunzima ukuyifaka kufomula futhi kulula ukwakha i-crystal precipitation. Ukuze kuxazululwe le nkinga, kunconywa ukwengeza i-isopropyl palmitate noma i-isopropyl myristate esigabeni samafutha esiqukethe i-kojic dipalmitate, ushise isigaba samafutha sibe ngu-80 ℃, ubambe imizuzu emi-5 kuze kube yilapho i-kojic dipalmitate incibilika ngokuphelele, bese ufaka isigaba samafutha esigabeni samanzi, bese uxuba cishe imizuzu eyi-10. Ngokuvamile, inani le-pH lomkhiqizo wokugcina otholiwe licishe libe ngu-5.0-8.0.
Umthamo onconywayo we-kojic dipalmitate ezimonyweni zokugcoba u-1-5%; Engeza u-3-5% emikhiqizweni yokwenza mhlophe.
Isikhathi sokuthunyelwe: Okthoba-21-2022