izindaba

Ukuze kunakekelwe isikhumba ngempumelelo, vele, akunakugwenywa ukuba nomqondo othile wezithako, hhayi nje kuphela ukukhuthazwa komkhiqizo, kodwa futhi nezithako zomkhiqizo. Namuhla, ake sixoxe “nge-carnosine” yezithako zemikhiqizo yokunakekelwa kwesikhumba.

Kuyini 'iCarnosine'
I-Carnosine iyi-dipeptide eyakhiwe yi-beta-alanine kanye ne-L-histidine, enokuqukethwe okuphezulu kwemisipha kanye nokuvinjelwa kobuchopho. I-Carnosine inezakhiwo eziphezulu ze-antioxidant futhi ingasusa ama-free radical emzimbeni.

Indlela 'i-carnosine' esebenza ngayo
I-Carnosine ingakhulisa ukumelana kwesikhumba, igcine isimo sobusha bamaseli ngokugcina umsebenzi wamaseli ku-full spectrum band kanye nezimo zama-free radical, ikhuthaze ukukhiqizwa kwe-collagen, futhi igcine isikhumba sinwebeka.

Indima 'ye-carnosine'
I-Carnosine ingakhulisa ukumelana kwesikhumba, igcine isimo sobusha bamaseli ngokugcina umsebenzi wamaseli ku-full spectrum band kanye nezimo zama-free radical, ikhuthaze ukukhiqizwa kwe-collagen, futhi igcine isikhumba sinwebeka. Uhlobo lwamakhemikhali lwe-I-L-carnosineukwakheka kwe-beta-alanine kanye ne-L-histidine ngesenzo se-carnosine synthase. I-Carnosine inamathuba amaningi okusetshenziswa emikhakheni yezokwelapha, ukunakekelwa kwempilo, kanye nokuhlanzeka ngenxa yezakhiwo zayo zokulwa ne-antioxidant, imiphumela yokususa ama-free radical, i-chelation enezinsimbi zokuguquka, ukuvikela izinzwa, ukukhuthaza ukuphulukiswa kwamanxeba, kanye nokulwa nokuguga.

1. Ukusetshenziswa kwe-carnosine embonini yokudla
Ingxenye eyinhloko yamafutha ekudleni ingxube yama-glycerides ahlukahlukene e-fatty acid. Ngenxa yokusabela kwama-free radical kwama-glycerides e-unsaturated fatty acid ngesikhathi sokugcinwa, kukhiqizwa ama-peroxide nama-aldehydes anephunga elimnandi noma ama-carboxylic acid anezinkinobho ezimfushane zekhabhoni. Ngakho-ke, ukudla ukudla okuqukethe ama-fat peroxide kuzothuthukisa kakhulu i-lipid peroxidation emizimbeni yabantu futhi kubangele izifo ezahlukahlukene. Ngakho-ke, i-butylated hydroxyanisole, i-dibutylated hydroxytoluene, i-propyl gallate, njll. zivame ukusetshenziswa ekucubungulweni nasekugcinweni kokudla ukuvimbela i-fat peroxidation, kodwa ukusebenza kwazo kuzoncishiswa enkambisweni yokushisa yokucubungula ukudla, futhi inobuthi obuthile. I-L-carnosine ayikwazi nje ukuvimbela i-fat oxidation ngempumelelo, kodwa futhi inomsebenzi wokuphepha ophezulu kanye nokunakekelwa kwempilo. Ngakho-ke, i-L-carnosine iyi-antioxidant yokudla ewusizo futhi efanelekile.
2. Ukusetshenziswa kwe-carnosine kwezokwelapha kanye nokunakekelwa kwempilo
(1) I-Carnosine kanye ne-Antioxidant

I-Carnosine ayikwazi ukusebenzisa i-athomu ye-imidazole ring N kanye ne-peptide bond N athomu kuma-residues e-histidine ukuze ikhiphe ama-ion ensimbi futhi ivimbele ukubola kwamafutha okubangelwa ama-ion ensimbi, kodwa futhi ne-histidine eketangeni eliseceleni le-carnosine inamandla okubamba ama-radical e-hydroxyl. Ingavimbela ukubola kwamafutha okubangelwa ama-ion angewona awensimbi. Ngakho-ke, njenge-antioxidant esebenzayo eminingi, i-carnosine ingavikela ulwelwesi lweseli ngokuzinzile futhi iyi-free radical scavenger encibilikayo emanzini. , ingavimbela ukubola kwelwelwesi lweseli. Uma kuqhathaniswa namanye ama-antioxidants ebhayoloji njenge-VC, i-carnosine inamandla amakhulu okulwa ne-antioxidant. Ngaphezu kokuvimbela inqubo yokubola kwelwelwesi lweseli, i-carnosine ingavimbela nochungechunge lwezinye izindlela zokusabela kwe-peroxidation ngaphakathi kweseli, okungukuthi, i-carnosine ingavimbela zonke izinyathelo zokusabela kwe-oxidation kulo lonke uchungechunge lwe-peroxidation emzimbeni. Indima yama-antioxidants afana ne-VC ukuvimbela ama-free radicals ukuthi angangeni ezicutshini, okungukuthi, angavimbela kuphela inqubo ye-liquid peroxidation ye-membrane yeseli, futhi awakwazi ukwenza lutho ngama-free radicals angene esitokisini.
(2) I-Carnosine kanye nesilonda esiswini

Isilonda se-Peptic yisifo sokugaya ukudla esingamahlalakhona emhlabeni wonke, futhi izici ezithile ezibangela izilonda azicaci kahle okwamanje, kodwa i-pathology ikholelwa ukuthi izici ezinamandla (njenge-asidi yesisu, ukukhishwa kwe-pepsin, ukutheleleka kwe-Helicobacter pylori) kanye nokuvimbela noma ukuvimbela amaseli Kubangelwa ukungalingani kwezinto ezivikelayo (ukukhishwa kwe-mucus, ukukhishwa kwe-bicarbonate, ukukhiqizwa kwe-prostaglandin). Indlela yemvelo yokuvikela isisu yile: yakha ungqimba olujiyile lwe-mucosa yesisu olusebenza njengesivikelo sokuvikela ukuvikela amaseli olwelwesini. Ukukhishwa okuqhubekayo kwe-mucous membrane kuvikela isisu, kodwa ukukhishwa ngokweqile kungabangela izilonda zesisu. Izifundo zithole ukuthi i-zinc-carnosine ethathwe ngokudla ingavimbela izilonda ngempumelelo, ingagcina ngempumelelo ubuqotho besisu kanye nendlela yaso yemvelo yokuvikela, lokhu kungenxa yezakhiwo ze-antioxidant ze-carnosine, ukuzinza kwe-membrane, umthethonqubo Izakhiwo ze-pharmacological zezicubu zomzimba kanye nokulungisa. Ngokusho kokuhlolwa kwemitholampilo, ngemuva kokuthatha i-zinc-carnosine amasonto ayisishiyagalombili, ama-70% eziguli ezithathe umuthi abonise ukuthuthuka okukhulu, kanti ama-65% ezilonda zesisu athuthukiswa nge-gastoscopy.
(3) Ukulawulwa kwe-carnosine kanye nokuzivikela komzimba

Impendulo yokuzivikela komzimba umsebenzi womzimba ogcina i-homeostasis futhi ulawulwa izinto ezisebenzayo ngokomzimba ezintweni eziphilayo. Ama-immunomodulators abhekisela ekwelapheni uhlobo lwezifo ezibangelwa ukungasebenzi kahle komzimba, futhi asetshenziselwa ukubuyisela impendulo yokuzivikela komzimba, ukuvimbela ukwehla kwawo okungavamile noma ukucindezela impendulo yawo esheshayo. Iningi lama-immunomodulators akhona akhiqizwa ngezindlela zokwenziwa kwamakhemikhali, ezinemiphumela ethile enobuthi kanye nemiphumela emibi. Izifundo zikhombisile ukuthi i-carnosine inomsebenzi wokulawula amasosha omzimba, futhi iyona kuphela into esebenzayo ngokomzimba etholakale kuze kube manje yokulawula amasosha omzimba, futhi isetshenziswe kabanzi ekwelapheni izifo nezifo ezahlukahlukene zokuzivikela komzimba ezibangelwa ukuzivikela okungavamile.