izindaba

Ukunakekelwa kwesikhumba okuphumelelayo, yiqiniso, akunakugwenywa ukuba nomqondo othile wezithako, hhayi nje ukukhuthazwa komkhiqizo, kodwa futhi izithako zomkhiqizo. Namuhla, ake sikhulume "nge-carnosine" yezithako zemikhiqizo yokunakekelwa kwesikhumba.

Yini 'i-Carnosine'
I-Carnosine iyi-dipeptide eyakhiwe i-beta-alanine ne-L-histidine, enokuqukethwe okuphezulu kwemisipha kanye namabhulokhi obuchopho. I-Carnosine ine-antioxidant ephezulu futhi ingakhipha ama-radicals mahhala emzimbeni.

Isebenza kanjani 'i-carnosine'
I-Carnosine ingakhuphula ukumelana kwesikhumba, igcine ubusha bamaseli ngokugcina ukusebenza kwamangqamuzana ebhandeni eligcwele le-spectrum kanye nezimo zama-radical mahhala, ikhuthaze ukukhiqizwa kwe-collagen, futhi igcine isikhumba sinwebeka.

Indima ye-'carnosine'
I-Carnosine ingakhuphula ukumelana kwesikhumba, igcine ubusha bamaseli ngokugcina ukusebenza kwamangqamuzana ebhandeni eligcwele le-spectrum kanye nezimo zama-radical mahhala, ikhuthaze ukukhiqizwa kwe-collagen, futhi igcine isikhumba sinwebeka. Imvelo yamakhemikhali yeI-L-carnosineukwakheka kwe-beta-alanine ne-L-histidine ngesenzo se-carnosine synthase. I-Carnosine inamathemba okusebenza abanzi emkhakheni wezokwelapha, ukunakekelwa kwezempilo, kanye nenhlanzeko ngenxa yezakhiwo zayo zokulwa ne-antioxidant, imiphumela yamahhala yokukhishwa kwe-radical, i-chelation enezinsimbi zoshintsho, i-neuroprotection, ukukhuthazwa kokuphulukiswa kwesilonda, nokulwa nokuguga.

1. Ukusetshenziswa kwe-carnosine embonini yokudla
Ingxenye eyinhloko yamafutha ekudleni ingxube ye-fatty acid glycerides ehlukahlukene. Ngenxa yokusabela kwe-radical yamahhala yama-unsaturated fatty acid glycerides ngesikhathi sokugcinwa, kukhiqizwa ama-peroxides nama-aldehyde anephunga elimnandi noma ama-carboxylic acid anamaketanga ekhabhoni amafushane. Ngakho-ke, ukudla ukudla okuqukethe ama-peroxides amafutha kuzothuthukisa i-lipid peroxidation emizimbeni yabantu futhi kubangele izifo ezihlukahlukene. Ngakho-ke, i-hydroxyanisole ye-butylated, i-hydroxytoluene e-dibutylated, i-propyl gallate, njll ivame ukusetshenziselwa ukucubungula ukudla nokugcinwa ukuze kuvinjelwe i-peroxidation yamafutha, kodwa ukusebenza kwayo kuzoncishiswa ekushiseni kokucubungula ukudla, futhi kunobuthi obuthile. I-L-carnosine ayikwazi ukuvimbela ngokuphumelelayo i-oxidation yamafutha, kodwa futhi inokuphepha okuphezulu nemisebenzi yokunakekelwa kwezempilo. Ngakho-ke, i-L-carnosine iyi-antioxidant yokudla ewusizo futhi ekahle.
2. Ukusetshenziswa kwe-carnosine kwezokwelapha kanye nokunakekelwa kwezempilo
(1) I-Carnosine ne-Antioxidant

I-Carnosine ayikwazi kuphela ukusebenzisa indandatho ye-imidazole engu-N ne-peptide bond N athomu ezinsalela ze-histidine ukuze i-chelate ion yensimbi futhi ivimbele i-oxidation yamafutha ebangelwa ama-ion ensimbi, kodwa futhi i-histidine eseceleni kweketango le-carnosine inamandla okuthwebula ama-hydroxyl radicals. Ingavimbela i-oxidation yamafutha ebangelwa ama-ion angewona ensimbi. Ngakho-ke, njengento esebenzayo ye-antioxidant esebenzayo, i-carnosine ingavikela ngokuzinzile ulwelwesi lwamaseli futhi iyi-scavenger yamahhala encibilika emanzini. , ingavimbela i-peroxidation ye-membrane yeseli. Uma kuqhathaniswa namanye ama-antioxidant ebhayoloji afana ne-VC, i-carnosine inomthamo onamandla wokulwa ne-antioxidant. Ngaphezu kokuvimbela inqubo ye-peroxidation ye-membrane yeseli, i-carnosine ingaphinde ivimbele uchungechunge lokunye ukusabela kwe-intracellular peroxidation, okungukuthi, i-carnosine ingavimbela zonke izinyathelo zokusabela kwe-oxidation kulo lonke uchungechunge lwe-peroxidation entweni ephilayo. Iqhaza lama-antioxidants afana ne-VC ukuvimbela ama-radicals mahhala ukuthi angangeni esicutshini, okungukuthi, angavimbela kuphela inqubo ye-peroxidation ye-liquid ye-membrane yeseli, futhi angeke enze lutho ngama-radicals mahhala angena engqamuzaneni.
(2) I-Carnosine nesilonda esiswini

I-Peptic ulcer yisifo esingalapheki emhlabeni jikelele sohlelo lokugaya ukudla, futhi izici ezithile ezibangela izilonda azikacaci kahle okwamanje, kodwa i-pathology ikholelwa ukuthi izici ezinolaka (njenge-gastric acid, secretion pepsin, Helicobacter pylori infection) kanye nokuvimbela noma amaselula ukungalingani kwezinto zokuzivikela (ukukhishwa kwamafinyila, ukukhishwa kwe-bicarbonate, ukukhiqizwa kwe-prostaglandin). Indlela yemvelo yokuvikela isisu yile: yakha ungqimba olujiyile lwe-gastric mucosa olusebenza njengesithiyo sokuzivikela sokuvikela amaseli olwelwesi. Ukugcinwa okuqhubekayo kolwelwesi lwamafinyila kuvikela isisu, kodwa ukukhishwa ngokweqile kungabangela izilonda zesisu. Ucwaningo luye lwathola ukuthi i-zinc-carnosine ethathwe ngokudla ingakwazi ukuvimbela ngokuphumelelayo izilonda, ingagcina ngokuphumelelayo ubuqotho besisu kanye nendlela yayo yokuzivikela yemvelo, lokhu kungenxa yezakhiwo ze-antioxidant ze-carnosine, ukuqina kwe-membrane, ukulawulwa kwezakhiwo ze-Pharmacological of immune kanye nokulungisa izicubu. Ngokwezivivinyo zemitholampilo, ngemva kokuthatha i-zinc-carnosine amasonto ayisishiyagalombili, u-70% weziguli ezathatha lesi sidakamizwa zabonisa ukuthuthuka okuphawulekayo, futhi i-65% yezilonda zesisu zenziwa ngcono nge-gastroscopy.
(3) I-Carnosine kanye nokulawulwa kwamasosha omzimba

Ukusabela kwamasosha omzimba kuwumsebenzi wokuphila ogcina i-homeostasis futhi kulawulwa izinto ezisebenza ngokusebenza komzimba ezintweni eziphilayo. Ama-Immunomodulators abhekisela ekwelapheni kwesigaba sezifo ezibangelwa ukungasebenzi kahle kwamasosha omzimba, futhi asetshenziselwa ukubuyisela impendulo yokuzivikela komzimba, avimbele ukwehla kwawo okungavamile noma acindezele impendulo yawo esheshayo. Iningi lama-immunomodulators akhona ahlanganiswa ngezindlela zokuhlanganisa amakhemikhali, ezinobuthi obuthile kanye nemiphumela engemihle. Ucwaningo luye lwabonisa ukuthi i-carnosine inomsebenzi we-immunomodulatory, futhi yiyona kuphela into esebenzayo ye-physiologically etholakala kuze kube manje ukuze i-immunomodulation, futhi isetshenziswe kabanzi ekwelapheni izifo ezihlukahlukene zokuzivikela komzimba kanye nezifo ezibangelwa ukungatheleleki okungavamile.