I-Polycaprolactone CAS 24980-41-4

I. Insimu Yokuphrinta ye-3D: Izinto ezisetshenziswayo ezifanele ukunemba okuphezulu nokwenza ngezifiso

Emkhakheni wokuphrinta kwe-3D (ukukhiqiza okungeziwe), i-polycaprolactone PCL isibe ngenye yezinto zokuphrinta ze-3D ezibolayo ezivamile ngenxa yephuzu layo eliphansi lokuncibilika (cishe ama-60℃), ukugeleza okuhle kokuncibilika kanye namandla okubopha phakathi kwezingqimba. I-PCL polymer ifaneleka kakhulu ezindleleni zobuchwepheshe ezifana ne-fused Deposition modeling (FDM) kanye ne-sterolithography, futhi isetshenziswa kabanzi kulezi zimo ezilandelayo:

Imodeli eyenzelwe wena kanye nokwenza ama-prototype:I-Polycaprolactone PCL inokushisa okulinganiselwe kokushintshashintsha kokushisa, okwenza kube lula ukugoba noma ukuqhekeka ngesikhathi senqubo yokuphrinta. Ingaphinda ngokunembile izakhiwo eziyinkimbinkimbi (njengeziqephu zezingxenye zemishini namamodeli amancane okwakha), futhi izingxenye eziphrintiwe zinobushelelezi obuphezulu bomphezulu, okungadingi ukucutshungulwa ngokweqile ngemva kokucubungula. Okwamanje, isici esiwohlokayo se-Polycaprolactone PCL siyenza ifanelekele izimo ze-prototype "zokusetshenziswa kanye" (njengeziqephu zezimoto ezivivinywayo), okunciphisa imfucuza yezinto ezibonakalayo.

Ukuphrinta kwe-3D kwezokwelapha Njengezinto ezihambisana kahle kakhulu kwe-bio:I-polycaprolactone PCL ivelele ekuphrinteni izicafu zobunjiniyela bezicubu. Ngokulungisa isisindo sama-molecule sezinto noma ngokuzihlanganisa nezinto ezisebenzayo njenge-hydroxyapatite (HA) ne-collagen, izicafu ezinezimbobo ezifanelana nezidingo zokukhula kwezicubu ezifana namathambo kanye ne-cartilage zingalungiswa. Isicafu singawohloka kancane kancane emzimbeni, sinikeze isikhala sokusekela izicubu ezintsha. Njengamanje, i-PCL polymer isetshenziswe ocwaningweni lokunyathelisa kwezokwelapha njengokulungisa amathambo kanye nokuvuselelwa kwesikhumba.

Emikhakheni yemfundo nobuciko:Indawo ephansi yokuncibilika kwe-polycaprolactone PCL ivumela ukuphrinta ngaphandle kwesidingo semishini yokushisa okuphezulu, okuqinisekisa ukuphepha okuphezulu. Ifaneleka njengezinto zokuqala zokuphrinta ze-3D ezimweni zemfundo. I-polycaprolactone PCL isetshenziselwa ukudala amamodeli okufundisa (njengamamodeli ezitho zomuntu kanye namamodeli esakhiwo sama-molecule amakhemikhali). Okwamanje, isici sayo sokuguquguquka kancane kancane ekushiseni kwegumbi siphinde sisekele insimu yokuklama yokudala ekwenzeni ukufakwa kobuciko noma izesekeli zamathoyizi ezinezimo ezilungisekayo.

Ii. Insimu Yokupakisha Ukudla Okulahlwayo: Iziqinisekiso ezimbili zokuwohloka okuluhlaza kanye nokuvikelwa kokuphepha

Emkhakheni wokupakisha ukudla okulahlwayo, i-polycaprolactone PCL isibe yindlela ebalulekile yokukhetha amapulasitiki endabuko angaboli (njenge-polyethylene ne-polypropylene) ngenxa yokubola kwayo ngokuphelele, izakhiwo ezinhle zokuvimbela kanye nokuphepha kokuxhumana kokudla, okusiza ekuxazululeni inkinga "yokungcola okumhlophe". Amafomu ayo okufaka isicelo ayinhloko afaka phakathi

Ifilimu/isikhwama sokupakisha ukudla okonakele:I-PCL ingaxutshwa futhi iguqulwe ngezinto zemvelo ze-polymer ezifana nesitashi kanye ne-polylactic acid (PLA) ukuze kuthuthukiswe ukuguquguquka kanye nokumelana namanzi kwezinto, futhi yenziwe amafilimu noma izikhwama zokulondoloza zokupakisha ukudla okusha (njengezithelo nemifino) kanye nokudla okuphekiwe - lolu hlobo lokupakisha lungasetshenziswa ezindaweni zemvelo (njengenhlabathi kanye nezimo zokufaka umquba) i-polycaprolactone PCL ingawohloka kancane kancane ibe yi-carbon dioxide namanzi zingakapheli izinyanga eziyi-6 kuya kweziyi-12 ngaphandle kokushiya noma yikuphi ukungcola okusele. Okwamanje, i-PCL polymer inokuqina okuhle kwamakhemikhali futhi ayisabelani namafutha noma izinto ezine-asidi ekudleni, ihlangabezana nezindinganiso zokuphepha zezinto zokuxhumana nokudla (njengesitifiketi se-FDA).

Izitsha zokudla ezilahlwayo kanye nezitsha zokudla:Ngokusebenzisa izinqubo zokubumba ngomjovo noma ngokucindezela okushisayo, i-polycaprolactone PCL ingahlanganiswa nemicu yezitshalo (njengemicu yotshani, imicu ye-bamboo) ukuze ikhiqize amabhokisi okudla kwasemini alahlwayo, amapuleti, imimese, amafoloko neminye imikhiqizo. Lolu hlobo lomkhiqizo alugcini nje ngokuba namandla okuthwala umthwalo omuhle kakhulu kanye nokumelana nokushisa (olukwazi ukumelana namazinga okushisa okudla ashisayo angu-60-80℃), kodwa i-polymer ye-PCL nayo ingonakaliswa ngokufaka umquba ngemva kokusetshenziswa, kugwenywe ukungcola kwemvelo kwesikhathi eside okubangelwa izitsha zokudla zepulasitiki zendabuko. Ifaneleka kakhulu ezimweni zokupakisha ezilahlwayo ezivame kakhulu njengokudla okuthathwayo kanye nokudla okusheshayo.

Iii. Insimu Yezinto Zephepha Lezokwelapha: Izinto eziyinhloko zokuhambisana kwezinto eziphilayo kanye nokuzivumelanisa nezimo zokusebenza

Emkhakheni wamapuleti ezokwelapha, i-polycaprolactone (PCL) isibe yinto ebalulekile yokukhiqiza amapuleti okulungisa ezokwelapha kanye namapuleti okuvikela ngenxa yokuphepha kwayo okuhle kakhulu kwe-biosafety, izinga lokuwohloka elilawulekayo kanye nezakhiwo zayo zemishini. Iziqondiso zayo eziyinhloko zokusetshenziswa zifaka:

Amabhodi okulungisa ezokwelapha:Emikhakheni efana nodokotela bamathambo kanye nodokotela bamazinyo, i-polycaprolactone PCL ingathuthukisa amandla ayo okusebenza ngokuguqulwa (njengokuhlanganisa i-hydroxyapatite kanye ne-triccalcium phosphate), futhi yenziwe amabhodi okulungisa amaphutha ethambo kanye namabhodi okwakha kabusha amathambo e-alveolar. Ngemva kokufakwa emzimbeni womuntu, lolu hlobo lwebhodi alukwazi nje ukunikeza ukwesekwa okusheshayo kwamathambo alimele kodwa futhi luwohloka kancane kancane kanye nokuvuselelwa kwamathambo omzimba, kugwenywe ingozi yokuhlinzwa kwesibili ukuze kususwe. Okwamanje, ukuhambisana kwe-polycaprolactone PCL kunganciphisa ukwenqatshwa kwamasosha omzimba ngemva kokufakelwa, kukhuthaze ukunamathela kwamaseli kanye nokuhlanganiswa kwezicubu, futhi kusetshenziswe emtholampilo ekuhlinzeni amathambo okulungisa amathambo okungenawo amandla amaningi.

Amabhodi okuvikela ezokwelapha kanye nokuhlukaniswa:I-PCL inezakhiwo ezinhle kakhulu zokwakha ifilimu kanye nezivimbelo futhi ingenziwa amabhodi okuhlukaniswa kwezokwelapha (njengamabhodi okuvikela udonga emakamelweni okuhlinzwa kanye nezendlalelo zokuhlukaniswa komhlaba zamadivayisi ezokwelapha). Lolu hlobo lwebhodi alugcini nje ngokuvimbela ngempumelelo ukungena kwamagciwane namagciwane, kodwa futhi lunokuguquguquka okuthile kanye nokumelana nokubulala amagciwane. Ingamelana nokusula okuphindaphindiwe ngezibulala-magciwane eziqukethe utshwala kanye ne-chlorine, futhi iyabola ngemva kokulahlwa, inciphise ingcindezi yokwelashwa kwemfucuza yezokwelapha. Ngaphezu kwalokho, i-polycaprolactone PCL ingahlanganiswa nama-antibacterial agents (njenge-silver ion) ukuze kuthuthukiswe ukusebenza okuhlala isikhathi eside kwamabhodi okuvikela, okwenza ifaneleke ezimweni ezinezidingo eziphezulu kakhulu zokuhlanzeka kwemvelo, njengeminyango yezifo ezithelelanayo kanye ne-icus.

Iv. Ezinye Izinkambu: Izinkambu zokwandisa ezisebenzayo

Ngaphezu kwezindawo eziyinhloko ezishiwo ngenhla, i-polycaprolactone PCL nayo idlala indima ezimweni eziningi:

Izimbozo kanye nezinamathiselo:I-polycaprolactone PCL, njengengxenye eyinhloko yokwakha ifilimu yezembozo ezisekelwe emanzini noma ezisekelwe ku-solvent, ingathuthukisa ukuguquguquka, ukumelana nokushayisana kanye nokumelana nesimo sezulu kwezembozo - isibonelo, uma isetshenziswa embozweni wangaphandle wodonga lwamapayipi ensimbi, inganciphisa ukuqhekeka kwezembozo ezibangelwa ukufinyela kwamapayipi ngenxa yokushintsha kwezinga lokushisa. I-polycaprolactone PCL isetshenziswa njengezembozo zangaphezulu zamathoyizi epulasitiki, okwenza izembozo zingagugi kakhulu futhi zingabi sengozini yokuqhekeka. Ngaphezu kwalokho, njengoba i-PCL ngokwayo ingenabo ubuthi, ingahlangabezana nezindinganiso zokuphepha zamathoyizi ezingane. Ngaphezu kwalokho, ukwengeza i-polymer ye-PCL ezimbozweni zokhuni kungathuthukisa nokuvezwa kombala wezinhlamvu zokhuni futhi kuthuthukise ukubukeka.

Izinto zezolimo:I-polycaprolactone PCL yenziwa amafilimu ezolimo abolayo, asetshenziselwa ukukhulisa izithombo zezitshalo, ukugcina amanzi kanye nomanyolo. Ngemva kokubola, angaguqulwa abe yizinto eziphilayo enhlabathini, kugwenywe ukungcoliswa komhlaba okubangelwa amafilimu asele. Noma angenziwa abe yithwali likamanyolo elikhipha kancane ukulawula izinga lokukhishwa kwezakhamzimba, kanti i-PCL polymer ingathuthukisa izinga lokusetshenziswa kukamanyolo. Isici "sokonakala okulawulwayo" se-PCL sihlangabezana kahle nezidingo zezolimo "zokusebenza" kanye "nobungani bemvelo", futhi sisetshenziswa kakhulu ukuxazulula izinkinga zokungcola kwezinto zendabuko zezolimo.

Isiguquli sezinto ezihlanganisiwe:I-polycaprolactone PCL ixutshwe nama-polyolefin, i-polyester nezinye izinto ukuze kuthuthukiswe ukuguquguquka kwazo kanye namandla azo okushaya, okwenza ifanelekele izimo ezinezidingo eziphezulu zokusebenza kwezinto, njengezingxenye zangaphakathi zezimoto kanye namagobolondo ezinto zasekhaya.

Ukuguqulwa kwefayibha/Indwangu:I-polycaprolactone PCL isetshenziselwa ukuguqula noma ukunamathisela imicu ye-polyester nekotini ukuze kuthuthukiswe ukuqina kwayo, ukumelana nokuguguleka kanye nezakhiwo zokulwa nemibimbi. Isibonelo, ukwengeza ukumboza kwe-PCL ezindwangu zezemidlalo kungenza izindwangu zeluleke kalula futhi zingabi sengozini yokuguquka. Ukuxhunyelelwa kwe-PCL kuma-fiber e-gauze yezokwelapha kungathuthukisa ukumuncwa komswakama kanye nokugcinwa kwe-gauze, kuthuthukise ukunamathela kwayo esikhumbeni, futhi kunciphise ukungakhululeki okubangelwa ukungqubuzana kwamanxeba.