Ukuhlolwa Kwekhwalithi Yokulethwa Okusheshayo Nokuhlanzeka Okuphezulu CAS 93-02-7 2, 5-Dimethoxybenzaldehyde

Silwela ukwenza kahle, ukusiza amakhasimende”, sithemba ukuba yiqembu elingcono kakhulu lokubambisana kanye nebhizinisi elibusayo labasebenzi, abahlinzeki kanye namakhasimende, libona ukwabelana ngenani kanye nokukhuthazwa okuqhubekayo Kokuhlolwa Kwekhwalithi Yokulethwa Okusheshayo kanye Nokuhlanzeka Okuphezulu CAS 93-02-7 2, 5-Dimethoxybenzaldehyde, Sizohlinzeka ngekhwalithi ephezulu esebenza kahle kakhulu, okungenzeka inani elinamandla kakhulu lomkhakha, kukhasimende ngalinye elisha namadala anazo zonke izinsiza ezingcono kakhulu eziluhlaza.
Silwela ukwenza kahle, ukusiza amakhasimende”, sithemba ukuba yiqembu elingcono kakhulu lokubambisana kanye nebhizinisi elibusayo labasebenzi, abahlinzeki kanye namakhasimende, eliqaphela ukwabelana ngenani kanye nokuphromotha okuqhubekayoChina Chemical Intermediates kanye Pharmaceutical Raw Materials, Ngenxa yokushintsha kwamathrendi kulo mkhakha, sizibandakanya ekuhwebeni kwempahla ngemizamo yokuzinikela kanye nokusebenza kahle kokuphatha. Sigcina amashejuli okulethwa ngesikhathi, imiklamo emisha, ikhwalithi nokungafihli lutho kumakhasimende ethu. I-Moto yethu ukuletha izixazululo zekhwalithi ngesikhathi esibekiwe.

I-2,5-Dimethoxybenzaldehyde iyimpushana yekristalu ephuzi ekhanyayo enesisindo semolekyuli esingu-166.18 kanye nephoyinti elibilayo elingu-146°C. Incibilika kuzincibilikisi zemvelo njenge-ethanol ne-ether. Isetshenziswa kakhulu njengendawo ephakathi yemithi.

Ngaphezu kokufakwa nge-oxid noma ukwehliswa ku-2,5-dimethoxybenzoic acid, i-benzonitrile noma i-benzyl alcohol, i-2,5-dimethoxybenzaldehyde ngokwayo nayo inenani eliyingqayizivele lohlelo lokusebenza. Ngokusabela ngezinto ezinezinhlobo ezahlukene zamaqembu asebenzayo, ama-molecule ezidakamizwa anezakhiwo ezahlukene kanye nemiphumela ehlukene angatholakala. Isifo sikaParkinson (PD) yisifo esivamile se-neurodeergenerative, futhi izimpawu zaso eziyinhloko zomtholampilo zihlanganisa ukundindizela kwemisipha, ukuqina, ubunzima bokunyakaza, ukuma komzimba kanye nokuphazamiseka kokulingana kokunyakaza. Ukuthuthuka okuqhubekayo kuzoholela ekuqashelweni, ekuboneni, ekuphazamisekeni kwenkumbulo kanye nokuwohloka komqondo okusobala. Njengamanje, ukwelashwa kwe-PD ikakhulukazi kuhlanganisa ukwelapha izidakamizwa, ukwelashwa ngokuhlinzwa kanye nokwelashwa ngofuzo. Ekwelashweni kwezidakamizwa, i-phenamidine itholakale inomthelela omuhle ku-PD, enobuthi obuphansi nokuphepha okuhle, futhi ukuhlanganiswa kwe-phenamidine kudinga ukusetshenziswa kwe-2,5-dimethoxybenzaldehyde njengento yokuqala.

Ngokwendlela yokuhlanganisa ebikwe ezincwadini, i-2,5-dimethoxybenzaldehyde itholakala ikakhulukazi ngokusabela i-1,4-dimethoxybenzene nge-ejenti ye-formylation. Ama-Formylation agents ahlanganisa (1) ingxube ye-1,1-dichloromethyl ether ne-titanium tetrachloride; (2) ingxube ye-N,N-dimethylformamide ne-phosphorus oxychloride, ingxube ye-N,N-dimethylformamide ne-oxalyl chloride; (3) ingxube ye-N,N-dimethylformamide ne-thionyl chloride noma ingxube ye-urotropine ne-magnesium chloride. Nokho, lezi zindlela zidinga ukusetshenziswa kwenani elikhulu le-titanium tetrachloride, i-phosphorus oxychloride noma i-thionyl chloride. Lawa ma-reagents azinzile futhi abola kalula, futhi inani elikhulu legesi le-hydrochloric acid likhishwa ngesikhathi sokusabela, elingahambisani nemvelo futhi linezidingo eziphezulu zenqubo yokusebenza.

Kuphakanyiswe indlela entsha yokuhlanganisa. Le ndlela isebenzisa i-1,4-dimethoxybenzene kanye ne-formaldehyde njengezinto zokusetshenziswa, futhi yenza ukuhlangana kwe-photooxidative lapho kukhona umoya-mpilo kanye ne-catalyst ngaphansi kwe-irradiation yokukhanya eluhlaza okwesibhakabhaka ukuze kuhlanganiswe kahle i-2,5-dimethoxybenzaldehyde. Le ndlela isebenzisa umoya-mpilo noma umoya njenge-oxidant, ayikhiqizi igesi ene-asidi, futhi ihambisana nemvelo. Ngaphezu kwalokho, le ndlela isebenzisa i-cobalt eshibhile njenge-catalyst, ephansi ngentengo futhi ifanele ukusetshenziswa kwezimboni.

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Silwela ukwenza kahle, ukusiza amakhasimende”, sithemba ukuba yiqembu elingcono kakhulu lokubambisana kanye nebhizinisi elibusayo labasebenzi, abahlinzeki kanye namakhasimende, libona ukwabelana ngenani kanye nokukhuthazwa okuqhubekayo Kokuhlolwa Kwekhwalithi Yokulethwa Okusheshayo kanye Nokuhlanzeka Okuphezulu CAS 93-02-7 2, 5-Dimethoxybenzaldehyde, Sizohlinzeka ngekhwalithi ephezulu esebenza kahle kakhulu, okungenzeka inani elinamandla kakhulu lomkhakha, kukhasimende ngalinye elisha namadala anazo zonke izinsiza ezingcono kakhulu eziluhlaza.
Ukuhlolwa Kwekhwalithi yeChina Chemical Intermediates kanye Pharmaceutical Raw Materials, Ngenxa yokushintsha kwamathrendi kulo mkhakha, sizibandakanya ekuhwebeni kwempahla ngemizamo yokuzinikela kanye nokusebenza kahle kokuphatha. Sigcina amashejuli okulethwa ngesikhathi, imiklamo emisha, ikhwalithi nokungafihli lutho kumakhasimende ethu. I-Moto yethu ukuletha izixazululo zekhwalithi ngesikhathi esibekiwe.