Usawoti we-disodium we-ATP CAS 987-65-5

Isithombe Esivelele se-ATP disodium salt CAS 987-65-5

I-CAS:987-65-5

Ubumsulwa:99%

Ifomula Yamamolekyuli:C10H17N5NaO13P3

Isisindo sama-molecule:531.18

I-EINECS:213-579-1

Isikhathi Sokugcina:iminyaka engu-2

Amagama afanayo:I-ADENOSINETRIPHOSPHATEDIUM; I-ADENOSINETRIPHOSPHATE, IDISODIUMSALT; I-ADENYLPYROPHOSPHORICACIDDISODIUMSALT; I-ADENOSINE-5′-TRIPHOSPHATE hydratedISODIUMSALT; I-ADENOSINE-5′-TRIPHOSPHATENA2-USALT; I-ADENOSINE-5′-TRIPHOSPHATENA2-USALT; I-ADENOSINE-5′-TRIPHOSPHORICACIDDISODIUMSALT; I-ADENOSINE-5′-TRIPHOSPHORICACIDDISODIUMSALT

Shiya Umlayezo Wakho

Imininingwane Yomkhiqizo

Landa

Amathegi Omkhiqizo

Iyini i-ATP disodium salt CAS 987-65-5?

Usawoti we-disodium we-ATP uyi-metabolite ye-adenosine, i-nucleoside triphosphate esebenza ngemisebenzi eminingi esetshenziswa njenge-coenzyme yokudluliselwa kwamandla kwangaphakathi kwamaseli kumaseli. Uthutha amandla amakhemikhali ngaphakathi kwamaseli ukuze kusetshenziswe i-metabolism. Usawoti we-disodium we-ATP usetshenziselwa ukuhlanganisa ama-analog e-deoxyadenosine diphosphate aguquliwe njenge-P2Y1 receptor ligands.

Imininingwane

Ukubukeka	Impuphu emhlophe noma engaphandle kwempuphu emhlophe noma i-crystal powder, e-hygroscopic.
Usayizi wezinhlayiya	＞95% idlula ku-80 mesh.
pH	2.5～3.5
Ukuncibilika	Incibilika emanzini; ayincibiliki ku-ethanol kanye ne-ether.
I-Oder	Oderless
Okuqukethwe kwamanzi	6.0%~12.0%
I-Chloride	≤0.05%
Usawoti wensimbi	≤0.001%
Izinsimbi ezisindayo	≤0.001%
Umholi	≤2.0ppm
I-Arsenic	≤1.0ppm

Isicelo

1. Ukusetshenziswa kocwaningo lwezimboni nolwesayensi
(1) Izinto zokusetshenziswa zobuhle: ezifakwe emikhiqizweni yokunakekelwa kwesikhumba elwa nokuguga, zingathuthukisa ukuqina kwesikhumba kanye nokucwebezela ngokwenza kusebenze i-metabolism yamandla eseli.
(2) Izithasiselo zokudla: ezisetshenziswa njengesithuthukisi sokudla eziphuzweni zezemidlalo kanye nokudla okusebenzayo ukuze kubuyiselwe amandla ngokushesha.
2. Izindawo zokwelapha zemitholampilo
(1) Izifo zesistimu yenhliziyo: ezisetshenziselwa ukwehluleka kwenhliziyo, i-myocarditis, i-myocardial infarction kanye ne-cerebral arteriosclerosis, njll., ngokuthuthukisa ukusebenza kahle kwamandla e-myocardial kanye nokwandisa imithambo yenhliziyo (ukwandisa ukugeleza kwegazi cishe ngo-30%), ukunciphisa izimpawu ze-ischemia yenhliziyo. Isibonelo, ezigulini ezine-acute myocardial infarction, i-ATP disodium inganciphisa isikhathi sokuwa kwe-ST segment futhi inciphise inani eliphakeme le-spectrum ye-myocardial enzyme.
(2) Izifo zesimiso sezinzwa: ukwelashwa okusizayo kwemiphumela yokopha kobuchopho, ukulimala kobuchopho kanye nokuwohloka kwemisipha okuqhubekayo, ngokungena emgoqweni wegazi nobuchopho (ukungena kwamanzi cishe kungama-65%), ukukhuthaza ukulungiswa kwe-membrane yamaseli ezinzwa kanye nokuvuselelwa kwenqubo yezinzwa, kanye nokuthuthukisa ijubane lokuqhutshwa kwezinzwa.
(3) Izifo ze-Metabolic: Ekwelapheni i-hepatitis kanye ne-cirrhosis, i-ATP disodium ingathuthukisa umsebenzi we-mitochondrial wama-hepatocytes, isheshise ukulungiswa kwe-hepatocyte, futhi yehlise amazinga e-ALT kanye ne-AST; futhi inomphumela wokuthuthukisa osizayo ezinkingeni zesifo sikashukela (njenge-peripheral neuropathy).
3. Izindawo zokufaka izicelo ezisafufusa
(1) Uhlelo lokulethwa kwemithi oluqondiwe: I-ATP disodium ingasetshenziswa njengesiguquli sokuthwala, kuhlanganiswe nama-liposome noma ama-nanoparticles, ukuze kufezwe ukulethwa kwemithi okuqondiwe nge-endocytosis eqondiswa yi-receptor. Isibonelo, ekwelashweni kwe-tumor, ama-nanomedicines aguquliwe yi-ATP angathuthukisa ukusebenza kahle kokubulala okukhethayo kwemithi ye-chemotherapy kumaseli omdlavuza.
(2) Ukukhuliswa kwamaseli kanye nemithi ye-biopharmaceuticals: Njengengxenye ebalulekile yendlela yokukhulisa amaseli, i-ATP disodium ingakhuthaza ukukhula kanye nokubonakaliswa kwamaprotheni kwamaseli e-CHO, amaseli e-HEK293, njll., futhi isetshenziswa kabanzi ekukhiqizweni kwama-antibody e-monoclonal.