I-Celastrol CAS 34157-83-0

Isithombe Esifakiwe se-Celastrol CAS 34157-83-0

I-CAS:34157-83-0

Ifomula Yamamolekyuli:C29H38O4

Isisindo sama-molecule:450.61

I-EINECS:636-472-5

Amagama afanayo:I-CELASTROL(SH); I-CELASTROL; I-Celastrol (i-Tripterin); I-CELASTROL(P)(SICELA USHAYE UCINGO); (20R)-3-Hydroxy-2-oxo-24-nor-D:A-friedoolean-1(10),3,5,7-tetren-29-oic acid; 2-Oxo-3-hydroxy-24-norfriedela-1(10),3,5,7-tetraene-29-oic acid; 2-Oxo-3-hydroxy-24-norfriedelane-1(10),3,5,7-tetraene-29-oic acidI-Celasterol

Shiya Umlayezo Wakho

Imininingwane Yomkhiqizo

Landa

Amathegi Omkhiqizo

Iyini i-Celastrol CAS 34157-83-0?

I-Celastrol ayincibiliki emanzini, incibilika ku-dimethyl sulfoxide kanye ne-anhydrous ethanol. Itholakala ezithakweni ezisebenzayo zokulwa nomdlavuza ezitshalweni ezifana ne-Thunder God Vine kanye ne-South Snake Vine emndenini we-Celastraceae. I-proteasome inhibitor esebenzayo, okuqinisekisiwe ukuthi ibangela i-cancer cell apoptosis ngokuvimbela umsebenzi we-proteasome.

Imininingwane

Into	Imininingwane
Indawo yokubilisa	645.7±55.0 °C (Kubikezelwe)
Ubuningi	1.2
Indawo yokuncibilika	219-230°C
i-pKa	4.78±0.70 (Kubikezelwe)
ubuningi be-λ	424nm(MeOH)(okukhanyayo)
Izimo zokugcina	-20°C

Isicelo

I-Celastrol isetshenziselwa ukunquma okuqukethwe/ukuhlonza/ukuhlolwa kwemithi, njll. Imiphumela yemithi: Inezakhiwo ezinamandla ze-antioxidant, imiphumela yokulwa ne-angiogenesis yomdlavuza, kanye nemiphumela yokulwa ne-rheumatoid. I-proteasome inhibitor esebenzayo, okuqinisekisiwe ukuthi ibangela i-apoptosis yamaseli omdlavuza ngokuvimbela umsebenzi we-proteasome.