I-Metronidazole CAS 443-48-1

Isithombe Esifakiwe se-Metronidazole CAS 443-48-1

I-CAS:443-48-1

Ifomula Yamamolekyuli:C6H9N3O3

Isisindo sama-molecule:171.15

I-EINECS:207-136-1

Amagama afanayo:I-TIMTEC-BB SBB001486; 1-(2-Hydroxy-1-ethyl)-2-methyl-5-nitroimidazole; 1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole; 1-(beta-Hydroxyethyl)-2-methyl-5-nitroimidazole; 1-(beta-Oxyethyl)-2-methyl-5-nitroimidazole; 1H-Imidazole-1-ethanol, 2-methyl-5-nitro-; 1H-Imidazole-1-ethanol, 2-methyl-5-nitro-; 1-Hydroxyethyl-2-methyl-5-nitroimidazole; 2-(2-Methyl-5-nitro-1H-imidazole-1-yl)ethanol; 2-Methyl-1-(2-hydroxyethyl)-5-nitroimidazole

Shiya Umlayezo Wakho

Imininingwane Yomkhiqizo

Landa

Amathegi Omkhiqizo

Iyini i-Metronidazole CAS 443-48-1?

I-Metronidazole iyimpuphu emhlophe noma ephuzi kancane ekristalu noma ekristalu; Kukhona iphunga elincane, elinokunambitheka okubabayo nokunosawoti kancane. Incibilika kancane ku-ethanol, incibilika kancane emanzini noma ku-chloroform, futhi incibilika kancane kakhulu ku-ether. I-Metronidazole iyinhlanganisela ye-heterocyclic equkethe i-nitrogen ene-alkalinity kanye nokuncibilika kwamanzi okuphansi. Ngokwesimiso se-prodrug, i-metronidazole yenziwa i-potassium phosphate ester, ekhulisa ukuncibilika kwayo emanzini futhi ingasetshenziswa njengesisombululo somjovo.

Imininingwane

Into	Imininingwane
Indawo yokubilisa	301.12°C (isilinganiso esilinganiselwe)
Ubuningi	1.3994 (isilinganiso esilinganiselwe)
Indawo yokuncibilika	159-161 °C (ngokukhanya)
i-pKa	i-pKa 2.62(H2O,t =25±0.2,
Izimo zokugcina	2-8°C

Isicelo

I-Metronidazole inomphumela oqinile wokulwa namagciwane kuma-bacteria amaningi angena-aerobic futhi isetshenziselwa ukwelapha i-amoebiasis, i-trichomoniasis, kanye nokutheleleka kwamagciwane angena-aerobic. Iphinde isetshenziswe ekwelapheni i-trichomoniasis yesitho sangasese sowesifazane futhi ibilokhu isetshenziswa kuma-amoebiasis amathumbu nangaphandle kwamathumbu kusukela ngo-1970. Ukusebenza kwayo kuphezulu, ubuthi buphansi, futhi isetshenziswa kabanzi. Inemiphumela yokuguquka kwezakhi zofuzo kanye ne-teratogenic ekuhlolweni kwezilwane.