I-SLU‑PP‑332 4‑I-Hydroxy‑N'‑(2‑naphthylmethylene)benzohydrazide CAS 303760‑60‑3

I-SLU‑PP‑332 CAS 303760‑60‑3iyinhlanganisela enamandla yocwaningo lwe-agonist ehlobene ne-pan-estrogen (ERR), i-white-off-white fine powder. Ibonisa ukuhambisana okuphezulu kwe-ERRα, i-ERRβ kanye ne-ERRγ ngamanani e-EC50 angu-98 nM, 230 nM kanye no-430 nM ngokulandelana. Le nhlanganisela ingathuthukisa ukusebenza kwe-mitochondrial kanye nokuphefumula kwamaseli emigqeni yamaseli emisipha yamathambo, esetshenziswa kabanzi ocwaningweni lwelebhu yezemfundo kanye nenqubo yemithi.

Izici Zomkhiqizo

✅ Ubumsulwa obuphezulu, obuhlolwe yi-HPLC, ukuqina okuzinzile kweqembu ngalinye

✅ Sula idatha yomsebenzi webhayoloji yocwaningo oluqondiwe lwe-ERR

✅ Iphakheji encane yelebhu iyatholakala, i-oda lesampula lokusekela

✅ Ukuncibilika okuhle ku-DMSO kokwenziwa kokuhlolwa kweseli

✅ Ukupakisha okuqinile okuvikela ukukhanya okuphansi ekushiseni ukuze kulondolozwe isikhathi eside