IHydroxypropyl beta-cyclodextrin, eyaziwa nangokuthi (2-hydroxypropyl) -β-cyclodextrin, i-athomu ye-hydrogen kumaqembu angu-2-, 3-, kanye ne-6-hydroxyl wezinsalela ze-glucose ku-β-cyclodextrin (β-CD) eshintshwa yi-hydroxypropyl ukuze i-hydroxypropoxy.I-HP-β-CD ayigcini nje ngokuba nomphumela omuhle kakhulu wemvilophu kumakhomponi amaningi afana ne-β-CD, kodwa futhi inezinzuzo zokuncibilika okuphezulu kwamanzi kanye nokuthuthukisa izinga lokukhululwa kanye nokutholakala kwezidakamizwa ezihlanganisiwe ku-vivo.Ukwengeza, i-HP-β-CD iyisamukeli somuthi esinedatha yokuphepha ebanzi kakhulu eqoqwe futhi ayikho imiphumela emibi.I-HP-β-CD ingasetshenziswa futhi njengesivikeli samaprotheni kanye nesiqinisi.
I-Hydroxypropyl beta-cyclodextrin imhlophe noma i-amorphous emhlophe noma i-crystalline powder;Ayinaphunga, imnandi kancane;Ukungeniswa komswakama okunamandla.Lo mkhiqizo uncibilika kalula emanzini, uncibilika kalula ku-methanol, ethanol, cishe awuncibiliki ku-acetone, trichloromethane.
Ukuncibilika kwei-hydroxypropyl -B-cyclodextrinemanzini kuhle kakhulu, futhi i-degree esikhundleni sika-4 nangaphezulu ingaxubana namanzi kunoma iyiphi ingxenye, futhi ingancibilika ku-50% we-ethanol ne-methanol.Ine-hygroscopicity ethile ehlobene.Kodwa umsebenzi wangaphezulu ohlobene nomsebenzi we-hemolytic uphansi kakhulu.Ayicasulwa imisipha futhi iyisithuthukisi se-solvent esifanelekile kanye nesakhi semithi yokujova.
Isetshenziselwa ini iHydroxypropyl beta-cyclodextrin?
Emkhakheni wokudla nezinongo
IHydroxypropyl beta-cyclodextrin ingathuthukisa ukuzinza nokusebenza kwesikhathi eside kwama-molecule omsoco, ivale noma ilungise iphunga elibi kanye nokunambitheka kwama-molecule omsoco wokudla, futhi ithuthukise inqubo yokukhiqiza kanye nekhwalithi yomkhiqizo.
Kwezimonyo
Izinto zokusetshenziswa zezimonyo zingasetshenziswa njengeziqinisi, ama-emulsifiers, ama-deodorizers, njll., ezinganciphisa ukugqugquzelwa kwamangqamuzana e-organic kuzimonyo esikhumbeni nezicubu zolwelwesi lwamafinyila, kuthuthukise ukuzinza kwezithako ezisebenzayo, futhi kuvimbele ukuvuvuka kanye ne-oxidation yezakhi. .Ine-hygroscopicity ethile ehlobene.
Emkhakheni wezokwelapha
IHydroxypropyl beta-cyclodextriningathuthukisa ukunyibilika kwamanzi kwezidakamizwa ezinganyibiliki, ikhulise ukuzinza kwezidakamizwa, ithuthukise i-bioavailability yezidakamizwa, ikhuphule ukusebenza kahle kwamalungiselelo ezidakamizwa noma inciphise umthamo, ilungise noma ilawule isivinini sokukhishwa kwezidakamizwa, futhi inciphise ubuthi bezidakamizwa.Ingasetshenziswa njengesithwali sezidakamizwa eziphuzwayo, imijovo, izinhlelo zokulethwa kwezidakamizwa ze-mucosal (okubandakanya i-nasal mucosa, i-rectum, i-cornea, njll.), amasistimu okulethwa kwezidakamizwa okumuncwa kwe-transdermal, izidakamizwa ezihlosiwe ze-lipophilic, futhi ingasetshenziswa njengesivikeli samaprotheni kanye isizinzisi.
Isikhathi sokuthumela: Oct-20-2023