izindaba

I-Hydroxypropyl beta-cyclodextrin, eyaziwa nangokuthi (2-hydroxypropyl) -β-cyclodextrin, iyi-athomu ye-hydrogen emaqenjini angu-2-, 3-, kanye no-6-hydroxyl wezinsalela ze-glucose ku-β-cyclodextrin (β-CD) ethathelwa indawo yi-hydroxypropyl ibe yi-hydroxypropoxy. I-HP-β-CD ayigcini nje ngokuba nomphumela omuhle kakhulu wokumboza amakhemikhali amaningi njenge-β-CD, kodwa futhi inezinzuzo zokuncibilika kwamanzi amaningi kanye nokuthuthukisa izinga lokukhululwa kanye nokutholakala kwemithi ehlanganisiwe emzimbeni. Ngaphezu kwalokho, i-HP-β-CD iyisithako semithi esinedatha yokuphepha ebanzi kakhulu eqoqwe futhi ayinayo imiphumela emibi emibi. I-HP-β-CD ingasetshenziswa futhi njengesivikelo seprotheni kanye nesiqinisi.

I-Hydroxypropyl beta-cyclodextrin iyimpuphu emhlophe noma emhlophe engaguquki noma ekristalu; Ayinaphunga, imnandi kancane; Ukufakwa komswakama okunamandla. Lo mkhiqizo uncibilika kalula emanzini, uncibilika kalula ku-methanol, i-ethanol, cishe awuncibiliki ku-acetone, i-trichloromethane.

Ukuncibilika kwei-hydroxypropyl-B-cyclodextrinemanzini muhle kakhulu, futhi izinga lokushintsha elingu-4 nangaphezulu lingaxutshwa namanzi nganoma yisiphi isilinganiso, futhi lingancibilikiswa ku-ethanol engu-50% kanye ne-methanol. Ine-hygroscopicity ethile. Kodwa umsebenzi wobuso ohlobene kanye nomsebenzi we-hemolytic uphansi kakhulu. Ayinawo ukucasuka emisipheni futhi iyisithuthukisi se-solvent esifanelekile kanye nesithako semithi somjovo.

I-Hydroxypropyl beta-cyclodextrin isetshenziselwa ini?

Emkhakheni wokudla nezinongo

I-Hydroxypropyl beta-cyclodextrin ingathuthukisa ukuzinza nokusebenza kwesikhathi eside kwama-molecule okunomsoco, ifihle noma ilungise iphunga elibi kanye nokunambitheka kwama-molecule okunomsoco wokudla, futhi ithuthukise inqubo yokukhiqiza kanye nekhwalithi yomkhiqizo.

Ezimonyweni

Izinto zokusetshenziswa zezimonyo zingasetshenziswa njengeziqinisi, ama-emulsifier, ama-deodorizers, njll., okunganciphisa ukukhuthazwa kwama-molecule ezinto eziphilayo ezimonyweni esikhumbeni nasezicutshini ze-mucous membrane, kuthuthukise ukuzinza kwezithako ezisebenzayo, futhi kuvimbele ukuguquguquka kanye nokushiswa kwezakhamzimba. Ine-hygroscopicity ethile ehlobene.

Emkhakheni wezokwelapha

I-Hydroxypropyl beta-cyclodextrinKungathuthukisa ukuncibilika kwamanzi kwemithi engancibiliki, kwandise ukuzinza kwemithi, kuthuthukise ukutholakala kwemithi, kwandise ukusebenza kahle kwemithi noma kunciphise umthamo, kulungise noma kulawule ijubane lokukhishwa kwemithi, futhi kunciphise ubuthi bemithi. Kungasetshenziswa njengesithwali semithi yomlomo, imijovo, izinhlelo zokulethwa kwemithi yomlomo (kufaka phakathi i-mucosa yamakhala, i-rectum, i-cornea, njll.), izinhlelo zokulethwa kwemithi yokumunca i-transdermal, izidakamizwa eziqondiswe ku-lipophilic, futhi kungasetshenziswa njengesivikelo seprotheni kanye nesiqinisi.